2021年のゲーム（物理・デジタル）トップ20をドル売上でランキングしたものを掲載する（データ提供はNPD）。

1 Call of Duty: Vanguard (Activision Blizzard)
2 Call of Duty: Black Ops: Cold War (Activision Blizzard)
3 Madden NFL 22 (EA)
4 Pokemon: Brilliant Diamond/Shining Pearl* (Nintendo)
5 Battlefield 2042 (EA)
6 Marvel's Spider-Man: Miles Morales (Sony)
7 Mario Kart 8* (Nintendo)
8 Resident Evil: Village (Capcom)
9 MLB: The Show 21^ (Sony)
10 Super Mario 3D World* (Nintendo)
11 Far Cry 6 (Ubisoft)
12 FIFA 22 (EA)
13 Minecraft (Microsoft)
14 Animal Crossing: New Horizons* (Nintendo)
15 NBA 2K22* (2K)
16 Assassin's Creed: Valhalla (Ubisoft)
17 Super Smash Bros. Ultimate* (Nintendo)*
18 Back 4 Blood (Warner Bros)
19 Mortal Kombat 11 (Warner Bros)
20 Forza Horizon 5 (Microsoft)