>>452一番目リンクより
>The pathophysiology of ADE is not yet well understood, but it appears
>to be closely related to low levels of neutralizing antibodies against RBD.
>However, it has been shown that ADE does not occur when antibodies bind
>to the nucleoprotein or any other structure different from RBD antigens (29).

>Antibodies directed against RBD are highly neutralizing,
>but are quite different between the two viruses
>(BCoV and SARS-CoV-2), as they target different domains.
>In contrast, antibodies directed towards the M protein may have cross-immunity
>among coronaviruses, binding selectively to Fc receptors (FcRs) (51).
>FcRs have interesting immunological functions including phagocytosis,
>degranulation, antibody-dependent cellular cytotoxicity (ADCC),
>cytokine formation, lipid mediator, and superoxide production (52).

RBD抗体の中和能力は高いが変異により中和能力が落ちた場合のリスクがある
その他の領域に対する抗体は中和能力が低くても実は侮れないかもしれない
M抗体の交差反応で有用な効果が期待できるようだ

>>418一番目リンクではHCoV-OC43 N抗体のレベルが高いと新コロで重症化しにくい
同二番目リンクではOC43 S抗体のレベルが高いと重症化しやすい(特に高齢者)
RBDはSタンパクに含まれOC43 S抗体は新コロに交差反応するが中和できない

もちろん抗体のみならず細胞性免疫も絡んでくるだろうが