0226名無しのアビガン(神奈川県)(ﾜｯﾁｮｲ f60b-JDnv)2022/03/26(土) 06:31:33.81ID:LG6/bGC80 COVID-19にイベルメクチンを使用した試験のストロンギロイドーシス有病率の高い地域と低い地域の比較 Comparison of Trials Using Ivermectin for COVID-19 Between Regions With High and Low Prevalence of Strongyloidiasis https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2790173
Helminth infection entails various forms of immunomodulation, resulting in an increased susceptibility to some infections, a decreased susceptibility to others, and changes in the intensity of allergic, autoimmune and inflammatory diseases; it has also been proposed that infection may account for inadequate responses to vaccines and, possibly, better tolerance of SARS-CoV-2 infection [5,80,81]. 0229名無しのアビガン(東京都)(ﾜｯﾁｮｲW 5e58-+ZSe)2022/03/26(土) 06:35:11.91ID:aL5z7uZW0>>227 晩節どころか花木って成果なくね？ 0230名無しのアビガン(千葉県)(ﾜｯﾁｮｲ 3180-q+eG)2022/03/26(土) 07:04:37.18ID:J/G0+k1O0 レベル低い工作員今日も来るのかな？ 0231名無しのアビガン(愛知県)(ﾜｯﾁｮｲW a2b5-D7/5)2022/03/26(土) 07:05:46.11ID:ifEedWIS0 安倍プーチンは？ 0232名無しのアビガン(愛知県)(ﾜｯﾁｮｲW d925-/loo)2022/03/26(土) 08:06:28.42ID:YVK+QraI0>>219 まあ別に観察研究が良い結果でない時に論文化しないことは悪いことじゃないけど、自分達のネガティブな観察研究を論文化しなかった体験があるならivmmetaが全く出版バイアスを考慮してないことくらいは気づいてほしかったな 凍結された匿名アカウントのツイートをソースとして解析に入れるのにデータベースに報告されたネガティブなRCTの結果は無視するivmmetaは出版バイアスとかいうレベルじゃないが 0233名無しのアビガン(愛知県)(ﾜｯﾁｮｲW d925-/loo)2022/03/26(土) 08:21:44.67ID:YVK+QraI0>>232 ソース
Helminth infection entails various forms of immunomodulation, resulting in an increased susceptibility to some infections, a decreased susceptibility to others, and changes in the intensity of allergic, autoimmune and inflammatory diseases; it has also been proposed that infection may account for inadequate responses to vaccines and, possibly, better tolerance of SARS-CoV-2 infection [5,80,81]. 0236名無しのアビガン(徳島県)(ﾜｯﾁｮｲ 4111-CxY7)2022/03/26(土) 09:05:12.09ID:1Kvyglq10>>213
The results revealed that IVM increased the frequency of epithelial tumor in D. melanogaster considering all evaluated concentrations, while AMX showed no carcinogenic effect.
Our current observation allows us to communicate for the first time the in vitro evaluation of DNA damage produced by these antiparasiticides: a brief 80 min pulse-treatment of 5.0–50.0 μg/ml of IVM or 25.0 and 50.0 μg/ml of ivomec®, resulted in a manifest level of single DNA-strand break induction. This findings are in concordance with previous observations showing a genotoxic effect exerted by the abamectin, the most active form of the avermectin (avermectin B1a), able to induce single strand DNA breaks in rat hepatocytes from rats treated in vivo [27].
IVM reduced testicular volume, tubular diameter and germinal epithelium height. Spermatogenesis interruption, such as degeneration morphology of the germ cells
Fig. 1. The effect of IVM on RAW264.7 cells. Cell viability inhibition of RAW264.7 cells treated with various concentrations of IVM (1.25, 2.5, 5,10,15 and 20 μM) for 24 h and 48 h. Small alphabets indicate significant differences (p < 0.05) between any two groups (A). Data are shown as the means ± SD of triplicate measurements.
ソース
Immunotoxicity induced by Ivermectin is associated with NF-κB signaling pathway on macrophages
Fig. 1. The effect of IVM on RAW264.7 cells. Cell viability inhibition of RAW264.7 cells treated with various concentrations of IVM (1.25, 2.5, 5,10,15 and 20 μM) for 24 h and 48 h. Small alphabets indicate significant differences (p < 0.05) between any two groups (A). Data are shown as the means ± SD of triplicate measurements.
ソース
Immunotoxicity induced by Ivermectin is associated with NF-κB signaling pathway on macrophages
Our current observation allows us to communicate for the first time the in vitro evaluation of DNA damage produced by these antiparasiticides: a brief 80 min pulse-treatment of 5.0–50.0 μg/ml of IVM or 25.0 and 50.0 μg/ml of ivomec®, resulted in a manifest level of single DNA-strand break induction. This findings are in concordance with previous observations showing a genotoxic effect exerted by the abamectin, the most active form of the avermectin (avermectin B1a), able to induce single strand DNA breaks in rat hepatocytes from rats treated in vivo [27].
IVM reduced testicular volume, tubular diameter and germinal epithelium height. Spermatogenesis interruption, such as degeneration morphology of the germ cells
