Genotoxicity and carcinogenicity of ivermectin and amoxicillin in vivo systems https://www.sciencedirect.com/science/article/pii/S1382668918302175? The results revealed that IVM increased the frequency of epithelial tumor in D. melanogaster considering all evaluated concentrations, while AMX showed no carcinogenic effect. 0005名無しのアビガン(北海道)(ｱｳｱｳｳｰ Sacd-7ygf)2022/03/28(月) 18:12:43.05ID:mMiq8uzPa チャイニーズハムスター細胞でDNA破壊を確認w やべえええ猛毒やんこれwww やっぱ古い薬はチェックが甘いからやべえの多いわなあww 最新技術で調べたらすぐに危険性が調べられるのになw https://www.sciencedirect.com/science/article/pii/S0304389408016178 Our current observation allows us to communicate for the first time the in vitro evaluation of DNA damage produced by these antiparasiticides: a brief 80 min pulse-treatment of 5.0–50.0 μg/ml of IVM or 25.0 and 50.0 μg/ml of ivomec®, resulted in a manifest level of single DNA-strand break induction. This findings are in concordance with previous observations showing a genotoxic effect exerted by the abamectin, the most active form of the avermectin (avermectin B1a), able to induce single strand DNA breaks in rat hepatocytes from rats treated in vivo [27]. 0006名無しのアビガン(北海道)(ｱｳｱｳｳｰ Sacd-7ygf)2022/03/28(月) 18:13:09.82ID:mMiq8uzPa イベルメクチンが人間の細胞でもDNA破壊することを確認！
イベルメクチンは広範な哺乳類の細胞に対して細胞生存率を著しく下げる毒性がある According to reports, IVM (1–280 μΜ) can significantly inhibit the cell viability of widely spread non-target mammalian cells (Molinari et al., 2009b, 2013). 本研究では人間の培養細胞に対してイベルメクチンがオートファジーを引き起こし細胞死を促すと判明 In the present study, we found that IVM-mediated proliferation inhibition in HeLa cells were markedly reverted by the addition of 3-MA. The result reflects that IVM can promote cell death by inducing autophagy in HeLa cells. イベルメクチンの細胞毒性メカニズムはAMPK/mTOR由来オートファジーおよびDNA酸化ダメージである可能性がある The mechanism of ivermectin’s cytotoxicity might be the AMPK/mTOR mediated autophagy and oxidative DNA damage. https://www.sciencedirect.com/science/article/pii/S0045653520316428?casa_token=grsoFiHgtasAAAAA:Rw1IbmA3vgPKjiGokdnzHyA5Rn0AeNvf7fruBmCUCJ2D2K0bUWw6wI7sTrQo4A8MTAo0n3-J0hZF
