0083名無しのアビガン(公衆) (エムゾネW FFbf-NOk9)
2022/02/09(水) 23:44:58.10ID:3NzFAqMfFthat bind allergen and prevent IgE engagement
https://www.nature.com/articles/s41467-018-03636-8
>we demonstrate that increasing the IgG/IgE ratio reduces
>the allergic response in mice and in cat-allergic patients
>greater correlation is observed when comparing symptom improvement with
>the ability of blocking IgG to compete with IgE for allergen binding9
>and functionally prevent the immediate hypersensitivity response14,15.
>These data suggest that augmenting the allergen-specific blocking
>IgG/IgE ratio is critically important to reducing allergic symptoms.
アレルゲンがIgEと結合しエフェクターを誘導することでアレルギーが発症するが
競合するIgGによってそれが抑制されることが猫アレルギーで確認されている
アレルゲン免疫療法(減感作療法)も
IgEと競合するIgGの増加により発症が抑制されると考えられる
O033 Bovine colostrum as an adjunct therapy in
the control of allergic respiratory disease in children
https://www.annallergy.org/article/S1081-1206%2816%2931020-1/fulltext
>Studies show that reduction in pro-inflammatory cytokines and
>the presence of IgG-allergen immune complexes in colostrum
>can prevent subsequent sensitization which may contribute
>to its beneficial effect in allergic diseases.
コロストラムには炎症性サイトカイン抑制作用があり更に
IgG-アレルゲン複合体が含まれIgEとの競合による効果が期待できる