Augmented antiviral T cell immunity by oral administration of IMM-124E in preclinical models and a phase I/IIa clinical trial: A method for the prevention and treatment of COVID-19 https://onlinelibrary.wiley.com/doi/10.1002/ddr.21890 健康な被験者への投与でT細胞を活性化しSARS-CoV-2スパイクタンパクへの 曝露時にインターフェロンγ産生の増加効果を示した臨床試験
0060名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FF8a-pkVJ)2021/12/21(火) 23:55:53.58ID:tRyLSq81F Cow Colostrum Supplementation Reduces Respiratory Distress in Covid Patients - Research Review https://indiancattle.com/bovine-colostrum-covid/ >Few medical practitioners in Pune also tried colostrum >in their patients and reported similar results. >A striking observation confirmed by the doctors was >that when colostrum was given to the COVID patients, >the acute respiratory distress, reduced within 1-2 days >and the patients’ comfort feel was very high. >The colostrum group patients’ hospital stay was >also shorter than the control.
>>1 "Early Recovery of COVID-19 ..." の研究を行った病院と同じ地域の開業医もコロストラムを COVID-19患者に投与したところ同様の効果が見られた 投与後1-2日で急性呼吸不全を抑え容態も良好 入院期間も短縮された
>I strongly recommend that there is no harm in giving >bovine colostrum @ 50-75 ml to COVID patients >from day 1 of expression of symptoms.
>The presence of cross-reactive S2-specific antibodies capable >of mediating Fc effector functions in early infection could >potentially ameliorate disease symptoms and severity.
>Initial concerns for antibody-dependent enhancement (ADE) >of COVID-19 were driven by the reported association of >higher SARS-CoV-2 antibody titers with severe disease.38 >However, this could simply be the result of prolonged >antigen exposure due to higher viral loads.
抗体価と重症度が比例することからADEへの懸念もあったが これは単にウイルス量が多く抗原への長い曝露の結果であろう 0064名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FFaf-tMh1)2021/12/27(月) 23:55:55.65ID:0JNSjkpkF The clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction (Lf/IgF) for the common cold: A double blind randomized study https://www.sciencedirect.com/science/article/abs/pii/S0965229912001720 抗体・ラクトフェリン濃縮乳清タンパクの投与で風邪を抑制 牛乳あり余ってるならこういうの作ればいいのに 0065名無しのアビガン(公衆)(ﾆｸｸｴW FFaf-tMh1)2021/12/29(水) 23:55:56.15ID:VosxLJfmFNIKU Therapeutic Potential of Milk Whey https://www.mdpi.com/2306-5710/3/3/31/htm > 3.4. Lactoferrin (Lf) >The concentration of lactoferrin … in bovine milk and colostrum >it is around 0.2 mg/mL and 1.5 mg/mL, respectively
> 3.5. Immunoglobulins (Igs) >The whey fraction of milk contains a major amount of immunoglobulins, >comprising approximately 10%-15% of total whey proteins.
とはいえ感染症対策で使うなら含有量をハッキリさせた方がいいし Igs・Lf濃縮品やコロストラムを入手できるならそちらがいいだろう 0066名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FFba-bVzE)2021/12/31(金) 20:00:00.82ID:7hb+obVCF The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review https://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2261 >some encouraging results have been reported,51, 52 >especially in relation to the decrease of symptom severity and >duration that, coupled with the optimal tolerance consistently >mentioned across the studies, may make the LF supplementation >an interesting area for further investigations. Additionally, >as a few trials focussing on SARS-CoV-2 have just been registered, >new data could become available in the near future,
COVID-19に対するラクトフェリンの効果について 治験数はまだ少ないが症状緩和や期間短縮の効果は明確で期待できる 進行中の治験もあり今後エビデンスも積み上がっていくだろう 0067名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FF62-NJ1V)2022/01/03(月) 23:55:56.12ID:NjuvbNUIF Lactoferrin supplements could be used as adjunct for COVID-19 and other respiratory tract infections https://www.news-medical.net/news/20211019/Lactoferrin-supplements-could-be-used-as-adjunct-for-COVID-19-and-other-respiratory-tract-infections.aspx >However, Dr Merchant argues that lots of >low cost lactoferrin supplements being sold online >are not of desired quality … >The natural form of lactoferrin isolated from the milk >by a specialized filtration process have superior >biological properties than the most lactoferrin products >that are chemically processed and treated.
>>61二番目論文の解説記事だが ラクトフェリンも抗体もデリケートなタンパクなので 加工工程が品質に与える影響は大きい 治験ごとに結果のバラツキが出ることがあるのも 品質が影響している可能性もある この辺は注意点 0068名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FF62-NJ1V)2022/01/05(水) 23:55:54.58ID:DFszqCRSF Natural resources to control COVID-19: could lactoferrin amend SARS-CoV-2 infectivity? https://peerj.com/articles/11303/ >both human and bovine LFs have a wide spectrum of inhibitory activity against >many types of human coronaviruses (HCoV-229E, HCoV-NL63, and HCoV-OC43), >which agrees with the results of the antiviral activities assay of >bLF/hLF against a pseudovirus of SARS-CoV-2 in all cell-lines tested.
ラクトフェリンは多くのHCoVや疑似SARS-CoV-2への抗ウイルス作用を持つ
>It is well-known that LF down-regulates the pro-inflammatory >cytokines TNF-α, IL-6, IL-1β, IFN-α, and IL-8. … >The orally administered lactoferrin for human volunteers >for 7–8 days at 100–200 mg daily improved the production of CD+3, CD+4, >and CD+8 lymphocytes population, and enhanced the T helper cells, >T cell cytotoxic activities, natural killer cell (NK) cytotoxicity, >and serum cytokine levels (Kawakami et al., 2015).
>Several studies have shown that microbial dysbiosis is >significant in patients with COVID-19 (Aktas et al., 2020; >Han et al., 2020; Xu et al., 2020b; Zuo et al., 2020). >It has been shown that some patients with COVID-19 suffer >from microbial dysbiosis, and the levels of Lactobacillus spp. >and Bifidobacteria spp. are reduced (Xu et al., 2020a).
>Available evidence suggests that the gut and lungs are part of >the common mucosal immune system. The system mainly comprises >gut-associated lymphoid tissue (GALT) and bronchial-associated >lymphoid tissue (BALT) (McGhee and Fujihashi, 2012).
これはその通りだがIgGなど他の有効成分を捨てるのは勿体ない 0075名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FF22-+11B)2022/01/19(水) 23:55:55.65ID:ZRABECqmF Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts https://www.nature.com/articles/s41467-021-27674-x >Our results are thus consistent with pre-existing non-spike cross-reactive >memory T cells protecting SARS-CoV-2-naïve contacts from infection
Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies https://www.translationalres.com/article/S1931-5244%2821%2900029-3/fulltext >In our study, we speculate that preexisting >OC43 HCoV IgGs to N protein could be protective
HCoV-OC43 N抗体にSARS-CoV-2への防御効果が見られる N抗体の中和活性は弱くてもFcエフェクターは作用すると考えられる コロストラムにはBCoVのS2,Mと共にN抗体も含まれているだろう 0076名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FF22-+11B)2022/01/21(金) 23:23:23.94ID:zWm5K0BCF Broadly Neutralizing Bovine Antibodies: Highly Effective New Tools against Evasive Pathogens? https://www.mdpi.com/1999-4915/12/4/473/htm > 2. The Long CDR H3 Is Generated Inefficiently in Humans > 3. Ultralong CDR H3 Are Prevalent in the Cow Ab Repertoire > 6. Long CDR H3 Structures Confer Broadly Neutralizing Anti-Viral Properties
>>43二番目論文と関連するがCDR(相補性決定領域)の長い抗体は 広域的な中和活性を持ちウイルスの変異にも適応しやすい そのような抗体はヒトでは生成され難いがウシでは優勢 0077名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FF7f-CnmT)2022/01/25(火) 23:23:22.87ID:fIfbhy6pF Bovine-derived antibodies and camelid-derived nanobodies as biotherapeutic weapons against SARS-CoV-2 and its variants: A review article https://www.sciencedirect.com/science/article/pii/S1743919122000103 >Multivalent nanobodies resist the mutations of the SARS-CoV-2 variant >through two mechanisms: increased avidity for the ACE2 binding domain and >identification of preserved epitopes that are not accessible to human antibodies [134].
>The study may also have implications for understanding >the allergy- and asthma-protective effects of farm milk and >living in a farm environment, as the holoBLG loaded with its ligands >might preferentially occur in nonprocessed, nondefatted milk.
>Studies have also shown that the ability of BLG to bind to ligands >such as retinol and palmitic acid is lost following heating,112 >just as the antioxidant activity in milk is reduced after heating,111,113 >while its antigenicity is increased at the same time.26,112
未処理の生乳にはホロ型のβ-ラクトグロブリンが含まれ 高温殺菌等の処理でアポ型に変質する 0081名無しのアビガン(千葉県)(ﾄﾞｺｸﾞﾛ MMdf-OH7v)2022/02/05(土) 06:50:20.40ID:krVue5ClM 熱処理で変化するって面白いね。低温殺菌ならどうなんだろ 0082名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FFbf-NOk9)2022/02/05(土) 23:29:59.54ID:47mF9WgPF>>81 Milk Processing Affects Structure, Bioavailability and Immunogenicity of β-lactoglobulin https://www.mdpi.com/2304-8158/9/7/874/htm >While initial conformational transitions occur at temperatures as low as 40 °C [52], >fully denatured β-lactoglobulin is only observed at temperatures exceeding 130 °C [53,54,55], >indicating that the denaturation process of β-lactoglobulin can be described as a multistep mechanism. >Generally, the midpoint of transition, at which abrupt large-scale loss >of α-helix structural elements is observed, is approximately 65 °C [55]
>β-lactoglobulin was shown to interact with MFGM proteins but both >homogenization and heat processing are prerequisites for this binding to occur [66].
あとホモジナイズ(均質化)も影響するようだ 0083名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FFbf-NOk9)2022/02/09(水) 23:44:58.10ID:3NzFAqMfF Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement https://www.nature.com/articles/s41467-018-03636-8 >we demonstrate that increasing the IgG/IgE ratio reduces >the allergic response in mice and in cat-allergic patients
>greater correlation is observed when comparing symptom improvement with >the ability of blocking IgG to compete with IgE for allergen binding9 >and functionally prevent the immediate hypersensitivity response14,15. >These data suggest that augmenting the allergen-specific blocking >IgG/IgE ratio is critically important to reducing allergic symptoms.
O033 Bovine colostrum as an adjunct therapy in the control of allergic respiratory disease in children https://www.annallergy.org/article/S1081-1206%2816%2931020-1/fulltext >Studies show that reduction in pro-inflammatory cytokines and >the presence of IgG-allergen immune complexes in colostrum >can prevent subsequent sensitization which may contribute >to its beneficial effect in allergic diseases.
コロストラムには炎症性サイトカイン抑制作用があり更に IgG-アレルゲン複合体が含まれIgEとの競合による効果が期待できる 0084名無しのアビガン(公衆)(222222W FF32-YLSX)2022/02/13(日) 22:22:22.34ID:i32OV8QmF222222>>82 Loss of allergy-protective capacity of raw cow's milk after heat treatment coincides with loss of immunologically active whey proteins https://pubs.rsc.org/en/content/articlelanding/2020/FO/D0FO01175D >In conclusion, we demonstrated that the allergy-protective effect of >raw cow's milk is lost after heating milk for 30 min at 65 °C or higher. >This loss of protection coincided with a reduction in >native immunologically active whey proteins.
>想いやり生乳は種類別特別牛乳です。厚生労働省発布の >乳等省令には、特別牛乳を以下のように定義しています。 >『搾乳した場所で直ちに容器詰めできること、施設の衛生基準や >牛乳の成分・菌数をクリアしていることを保健所が認めると、種類別 >「特別牛乳」と表示できる。保健所の厳しい監視、指導が常時行われる』。 >現在、特別牛乳は全国で4社が製造しています。 >無殺菌牛乳は想いやりファーム１社、他は低温殺菌牛乳です。 0086名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FF1f-OIP+)2022/02/23(水) 23:23:23.51ID:vXPrr6dsF Milk of cow and goat, immunized by recombinant protein vaccine ZF-UZ-VAC2001(Zifivax), contains neutralizing antibodies against SARS-CoV-2 and remains active after standard milk pasteurization https://www.biorxiv.org/content/10.1101/2022.02.14.480298v1.full https://www.biorxiv.org/content/biorxiv/early/2022/02/15/2022.02.14.480298/F1.large.jpg >We showed an optimal regime for immune milk pasteurization at 62.5°C for 30 min, >which retained specific neutralizing activity to SARS-CoV-2, >potentially useful for passive immunization against coronavirus infection threats.
SARS-CoV-2免疫化したウシ・ヤギから中和抗体を含む乳を得られるが やはり65℃前後で抗体価が落ちる 62.5℃30分の加熱がよいのではないかとしている 0087名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FFea-jUJk)2022/03/02(水) 23:23:22.94ID:jl5qrc64F Immune milk in the treatment of hay fever https://www.jacionline.org/article/0021-8707%2860%2990011-3/fulltext 1960年の研究で初乳は花粉症への効果無しと結論してたが
>colostrum was collected and processed into dried skimmed milk >by the usual commercial methods which involve heating >to 160°-180°F. (71°-82°C.) for a half hour.
この加熱処理で台無しになってたのだろう 0088名無しのアビガン(神奈川県)(ﾜｯﾁｮｲW 9b09-0VEH)2022/03/11(金) 22:12:33.75ID:GXOJZobo0 これ飲んでるからか今年は花粉症平気だ 屋外ノーマスク余裕 0089名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FFa2-t+WT)2022/03/12(土) 21:44:44.27ID:u4w1agczF 生乳廃棄の恐れ、再び 給食需要減で年度末から―乳業業界 https://www.jiji.com/jc/article?k=2022031001297 また… 0090名無しのアビガン(公衆)(ｵｰﾊﾟｲW FFa2-W/6I)2022/03/14(月) 21:22:32.91ID:dXExx6hWFPi 花粉ピークで鼻水垂れてきたが 飲む量倍にしたら治まった 0091名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FF33-thsf)2022/03/22(火) 23:33:34.58ID:jtwINlZTF Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus https://www.biorxiv.org/content/10.1101/2021.12.13.472476v1.full BCoV抗体を含むコロストラムの摂取が SARS-CoV-2にも有効というのがこのスレのテーマであるが ヒトがBCoVへ曝露することで得られる免疫もまた有効でないかという話 0092名無しのアビガン(神奈川県)(ﾆｸｸｴW 5e09-OkJ+)2022/03/29(火) 23:50:50.45ID:DpR4kOfV0NIKUhttps://agri-kanagawa.jp/sinrinken/12kahun/kahun_22.htm スギは終盤でヒノキに移ってきてる ヒノキは元々平気だから無事に乗り切れそうだ 0093名無しのアビガン(公衆)(ｴﾑｿﾞﾈW FFb2-2K8+)2022/03/30(水) 23:50:00.39ID:/PHab0s9F Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements https://www.mdpi.com/2072-6643/14/3/659/htm このスレでも触れられてることが色々纏まってる 0094名無しのアビガン(三重県)(ﾆｸｸｴW 229c-YX0t)2022/04/29(金) 17:57:55.98ID:5bPLjuIY0NIKU Avoid Colostrum Supplements
Oral bovine colostrum supplementation does not increase circulating insulin-like growth factor-1 concentration in healthy adults: results from short- and long-term administration studies https://link.springer.com/article/10.1007/s00394-019-02004-6 >concerns have been raised that if circulatory IGF-1 >is raised in response to colostrum supplementation, >prolonged administration of colostrum might stimulate >malignancy in distant organs such as prostate cancer >which is known to commonly express IGF-1 receptors [13].
>In summary, we conclude that ingestion of standard doses of >colostrum (20–40 g/day) in healthy adult subjects does not result >in an immediate or long-term increase in circulating IGF-I levels. 0096名無しのアビガン(三重県)(ﾜｯﾁｮｲW df9c-3KYT)2022/04/30(土) 17:26:30.02ID:Bm59HIQR0>>95 どうも有難う 0097名無しのアビガン(神奈川県)(ﾜｯﾁｮｲW 85b9-lH20)2022/07/15(金) 08:08:08.24ID:8z17oJMZ0 新型コロナウイルスを中和するアルパカ抗体―オミクロンを含む全ての変異株に有効― https://www.kyoto-u.ac.jp/ja/research-news/2022-07-14
An Ultralong Bovine CDRH3 that Targets a Conserved, Cryptic Epitope on SARS-CoV and SARS-CoV-2 https://www.biorxiv.org/content/10.1101/2022.04.06.487306v1.full0098名無しのアビガン(神奈川県)(ﾜｯﾁｮｲ a3b9-M72W)2023/01/01(日) 09:11:11.79ID:8p0XTSBp0 Bovine colostrum supplementation in prevention of upper respiratory tract infections – Systematic review, meta-analysis and meta-regression of randomized controlled trials https://www.sciencedirect.com/science/article/pii/S1756464622003863 https://ars.els-cdn.com/content/image/1-s2.0-S1756464622003863-gr2_lrg.jpg https://ars.els-cdn.com/content/image/1-s2.0-S1756464622003863-gr5_lrg.jpg https://ars.els-cdn.com/content/image/1-s2.0-S1756464622003863-gr6_lrg.jpg コロストラムがURTI(上気道感染症≒風邪)を抑える効果についてのメタアナリシス 0099名無しのアビガン(大阪府)(ﾜｯﾁｮｲW 8fee-/ffz)2023/01/21(土) 01:29:43.59ID:a1R0o0wF0 テステス 0100名無しのアビガン(騒)(ﾜｲｰﾜ2 FF93-WELw)2023/02/20(月) 20:22:55.74ID:J6ftN4XHF>>83二番目は有料記事だが↓で部分的に読める https://www.sciencedirect.com/science/article/abs/pii/S1081120616310201 RCTで有意な効果が示された 0101名無しのアビガン(騒)(ﾜｲｰﾜ2 FF92-GLWX)2023/04/25(火) 20:59:10.17ID:BtRDxvkYF Moderate Dose Bovine Colostrum Supplementation in Prevention of Upper Respiratory Tract Infections in Medical University Students: A Randomized, Triple Blind, Placebo-Controlled Trial https://www.mdpi.com/2072-6643/15/8/1925 病原体への曝露など感染リスクの高い医学生で コロストラムはURTI(上気道感染症≒風邪)への防御効果を示した 0102名無しのアビガン(騒)(ﾜｲｰﾜ2 FF33-JLeH)2023/08/09(水) 22:00:00.10ID:4HQ1V4EzF SARS coronavirus 2-reactive antibodies in bovine colostrum https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031788/ SARS-CoV-2に交差反応する抗体がウシ初乳に含まれている BCoVと共通のエピトープによるものと考えられる
Hen egg white bovine colostrum supplement reduces symptoms of mild/moderate COVID-19: a randomized control trial https://www.future-science.com/doi/10.2144/fsoa-2023-0024 初乳＋卵白のサプリでCOVID-19の症状が緩和されたというRCT 0103名無しのアビガン(大阪府)(ﾜｯﾁｮｲW f91b-ZMgz)2023/08/22(火) 13:47:54.30ID:y071JOut0 マァァァ━━━（゜Д゜；ノ）ノ━━━ジデェェェ！？？ 0104名無しのアビガン(騒)(ﾜｲｰﾜ2 FFf2-mJV9)2023/08/27(日) 23:45:00.78ID:VZqJnYNSF Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children https://www.mdpi.com/2072-6643/15/16/3626 コロストラムで未就学児のURTI(上気道感染症≒風邪)を抑制 試験は21週間でコロストラム投与は最初の45日間 20週目でも罹患日数31%↓・症状の重さ37%↓の有意な効果を示した 0105名無しのアビガン(東京都)(ﾜｯﾁｮｲW 6baa-yeAs)2023/09/29(金) 07:19:38.54ID:YzpBjv330 ちょっとウインドウショッピングしてこようかな。 0106名無しのアビガン(調整中)(ﾜｯﾁｮｲW 1b2d-dY66)2023/10/02(月) 09:42:07.35ID:PPkOV/Kr0 もうバカバカしいんだけど 0107名無しのアビガン(調整中)(ﾜｯﾁｮｲW 2d0b-GXbC)2023/10/03(火) 12:45:34.26ID:bGnaLSsv0 なんやかんや言いよるなぁ。 0108名無しのアビガン(群馬県)(ﾜｯﾁｮｲW 3d25-C1jH)2023/10/05(木) 07:45:50.87ID:rzUfwXgy0 (゜ロ゜)ギョェ 0109名無しのアビガン(愛知県)(ﾜｯﾁｮｲW 0170-GVoV)2023/10/19(木) 08:29:57.55ID:KYSjOBzv0 「え！？今から魔王戦！？良いけど……今からバイトなんですよね～ 0110名無しのアビガン(騒)(ﾜｲｰﾜ2 FF8a-SW3h)2023/11/05(日) 23:44:59.98ID:3wqmjB0vF Bovine colostrum and its potential contributions for treatment and prevention of COVID-19 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613682/ コロストラムに含まれる成分の効能や これまで行われたRCT等のレビュー
